While reports of certain issues were unique to the antidepressants, such as the onset of premature ejaculation and persistent genital arousal disorder PGAD , there was also a significant...
Open in a separate window. While neither genital anaesthesia nor pleasureless orgasm are features of depression or anxiety [ 4 ], and patients typically have normal functioning prior to starting an antidepressant, physicians appear to default to attributing problems a patient has after treatment to manifestations of an underlying nervous diathesis.
This numbing is comparable to the effect of local anaesthetics such as lidocaine, and underpins the use of both SSRIs and local anaesthetics in the management of premature ejaculation. PSSD is a debilitating condition that adversely affects quality of life. Rodents given fluoxetine were found to have sustained desensitisation of 5-HT1A receptors after removal of the drug [ 28 ]. Effectiveness mechanism of chlomipramine by neurophysiological tests in subjects with true premature ejaculation.
The symptoms, classification, pathophysiology, diagnostic considerations, and management of PSSD were reviewed.
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Fascinating as these possibilities are, clinically the priorities are to raise awareness of these issues among patients and professionals, and to find treatments for a debilitating set of conditions that can have a profound impact on quality of life. Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients. In cases of enduring dysfunction, finasteride and isotretinoin appear to induce genital effects comparable to those found with serotonin reuptake inhibitors.
Waldinger et al reported on a subject with penile anaesthesia following paroxetine use, whose penis was insensitive to the effect of Tiger Balm [ 8 ]. A double-blind, placebo-controlled, fixed-dose, randomized study.
Prepublished online May 1.